How sensory information is processed and how it is modulated by other brain areas is a key question in systems neuroscience. The long-term goal of our research is to understand how neuronal networks in different parts of the brain interact during perception and how this information is used in processes of learning and decision-making. Using two-photon imaging, multi electrode recordings, optogenetics, intracellular patch clamp recordings and psychophysics, we are investigating how cortical microcircuits interact to produce a behavioral output.